The Gene for Familial Polyposis Coli Maps to the Long Arm of Chromosome 5

Leppert, M.; Dobbs, M.; Scambler, Peter; O’Connell, P.; Nakamura, Yusuke; Stauffer, Dora; R. Woodward, Scott; W. Burt, Randall; Hughes, Jaime; J. Gardner, Eldon; Lathrop, Mark; J. Wasmuth, John; Lalouel, J.-M.; White, R.

doi:10.1126/science.3479843

Public

The Gene for Familial Polyposis Coli Maps to the Long Arm of Chromosome 5

Published in Science • Dec 4, 1987

Authors:

M. Leppert

M. Dobbs

Peter Scambler

Abstract

The inherited genetic defect in adenomatous polyposis has been localized to a small region on the long arm of chromosome 5. Sixteen DNA marker loci were used to construct a linkage map of the chromosome. When five kindreds segregating a gene for adenomatous polyposis coli were characterized with a n...

Subject

Genetics

Genetic linkage

Biology

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