Early-Onset Familial Alzheimer's Disease (EOFAD)

Wu, Liyong; Rosa-Neto, Pedro; R. Hsiung, Ging-Yuek; Dessa Sadovnick, A.; Masellis, Mario; E. Black, Sandra; Jia, Jianping; Gauthier, Serge

doi:10.1017/s0317167100013949

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Early-Onset Familial Alzheimer's Disease (EOFAD)

Shared by NobleBlocks on Jul 1, 2012 • 12:00 AM UTC

Authors:

Liyong Wu

Pedro Rosa-Neto

Ging-Yuek R. Hsiung

Abstract

Early-onset familial Alzheimer's disease (EOFAD) is a condition characterized by early onset dementia (age at onset < 65 years) and a positive family history for dementia. To date, 230 mutations in presenilin (PS1, PS2) and amyloid precursor protein (APP) genes have been identified in EOFAD. The mut...

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