The activation of Akt/PKB signaling pathway and cell survival

Song, Gang; Ouyang, Gaoliang; Bao, Shideng

doi:10.1111/j.1582-4934.2005.tb00337.x

Public

The activation of Akt/PKB signaling pathway and cell survival

Published in Journal of Cellular and Molecular Medicine • Jan 1, 2005

Authors:

Gang Song

Gaoliang Ouyang

Shideng Bao

Abstract

Akt/PKB is a serine/threonine protein kinase that functions as a critical regulator of cell survival and proliferation. Akt/PKB family comprises three highly homologous members known as PKBalpha/Akt1, PKBbeta/Akt2 and PKBgamma/Akt3 in mammalian cells. Similar to many other protein kinases, Akt/PKB c...

Subject

Protein kinase B

AKT1

AKT2

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