High-pressure selectivity studies--a simple route to a homochiral wistarin precursor.

C, Knappwost-Gieseke; F, Nerenz; R, Wartchow; E, Winterfeldt

doi:10.1002/chem.200204524

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High-pressure selectivity studies--a simple route to a homochiral wistarin precursor.

Shared by NobleBlocks on Aug 1, 2003 • 12:00 AM UTC

Authors:

Knappwost-Gieseke C

Nerenz F

Wartchow R

Abstract

The cycloaddition of spirobutenolide 3 to the homochiral cyclopentadiene 1 at 6.5 kbar leads exclusively to cycloadduct 5. Subsequent Diels-Alder or Michael additions again favour the cyclohexenone double bond; this perfect chemo- regio- and face selectivity was employed for a short and efficient ap...

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