The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-alpha converting enzyme (TACE).

Pan, Beiqing; N Farrugia, Amanda; Bik To, Luen; M Findlay, David; Green, Jonathan; Lynch, Kevin; C W Zannettino, Andrew

doi:10.1359/jbmr.2004.19.1.147

Public

The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-alpha converting enzyme (TACE).

Shared by NobleBlocks on Jan 1, 2004 • 12:00 AM UTC

Authors:

Beiqing Pan

Amanda N Farrugia

Luen Bik To

Abstract

Bisphosphonates are used to prevent osteoclast-mediated bone loss. Zoledronic acid inhibits osteoclast maturation indirectly by increasing OPG protein secretion and decreasing transmembrane RANKL expression in human osteoblasts. The decreased transmembrane RANKL expression seems to be related to the...

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