Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

Bordone, Laura; Carla Motta, Maria; Picard, Frédéric; Robinson, Ashley; S. Jhala, Ulupi; Apfeld, Javier; McDonagh, Thomas; E. Lemieux, Madeleine; W. McBurney, Michael; Szilvasi, Akos; Easlon, Erin; Lin, Su-Ju; Guarente, Leonard

doi:10.1371/journal.pbio.0040031

Public

Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

Published in PLoS Biology • Dec 20, 2005

Authors:

Laura Bordone

Maria Carla Motta

Frédéric Picard

Abstract

Sir2 and insulin/IGF-1 are the major pathways that impinge upon aging in lower organisms. In Caenorhabditis elegans a possible genetic link between Sir2 and the insulin/IGF-1 pathway has been reported. Here we investigate such a link in mammals. We show that Sirt1 positively regulates insulin secret...

Subject

Biology

Insulin

Gene knockdown

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!