Integrated expression profiling and genome-wide analysis of ChREBP targets reveals the dual role for ChREBP in glucose-regulated gene expression.

Jeong, Yun-Seung; Kim, Deokhoon; Seok Lee, Yong; Kim, Ha-Jung; Han, Jung-Youn; Im, Seung-Soon; Kim Chong, Hansook; Kwon, Je-Keun; Cho, Yun-Ho; Kyung Kim, Woo; F Osborne, Timothy; D Horton, Jay; Jun, Hee-Sook; Ahn, Yong-Ho; Ahn, Sung-Min; Cha, Ji-Young

doi:10.1371/journal.pone.0022544

Public

Integrated expression profiling and genome-wide analysis of ChREBP targets reveals the dual role for ChREBP in glucose-regulated gene expression.

Shared by NobleBlocks on Jan 1, 2011 • 12:00 AM UTC

Authors:

Yun-Seung Jeong

Deokhoon Kim

Yong Seok Lee

Abstract

The carbohydrate response element binding protein (ChREBP), a basic helix-loop-helix/leucine zipper transcription factor, plays a critical role in the control of lipogenesis in the liver. To identify the direct targets of ChREBP on a genome-wide scale and provide more insight into the mechanism by w...

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