Integrated Expression Profiling and Genome-Wide Analysis of ChREBP Targets Reveals the Dual Role for ChREBP in Glucose-Regulated Gene Expression

Jeong, Yun-Seung; Kim, Deokhoon; Seok Lee, Yong; Kim, Ha-Jung; Han, Jung-Youn; Im, Seung‐Soon; Kim Chong, Hansook; Kwon, Je-Keun; Cho, Yun-Ho; Kyung Kim, Woo; F. Osborne, Timothy; D. Horton, Jay; Jun, Hee‐Sook; Ahn, Yong‐Ho; Ahn, Sung‐Min; Cha, Ji-Young

doi:10.1371/journal.pone.0022544

Public

Integrated Expression Profiling and Genome-Wide Analysis of ChREBP Targets Reveals the Dual Role for ChREBP in Glucose-Regulated Gene Expression

Published in PLoS ONE • Jul 21, 2011

Authors:

Yun-Seung Jeong

Deokhoon Kim

Yong Seok Lee

Abstract

The carbohydrate response element binding protein (ChREBP), a basic helix-loop-helix/leucine zipper transcription factor, plays a critical role in the control of lipogenesis in the liver. To identify the direct targets of ChREBP on a genome-wide scale and provide more insight into the mechanism by w...

Subject

Carbohydrate-responsive element-binding protein

Biology

Chromatin immunoprecipitation

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