Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

Kleinnijenhuis, Johanneke; Quintin, Jessica; Preijers, Frank; A. B. Joosten, Leo; C. Ifrim, Daniela; Saeed, Sadia; Jacobs, Cor; van Loenhout, Joke; de Jong, Dirk; G. Stunnenberg, Hendrik; J. Xavier, Ramnik; van der Meer, J.W.M.; van Crevel, Reinout; G. Netea, Mihai

doi:10.1073/pnas.1202870109

Public

Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

Published in Proceedings of the National Academy of Sciences • Sep 17, 2012

Authors:

Johanneke Kleinnijenhuis

Jessica Quintin

Frank Preijers

Abstract

Adaptive features of innate immunity, recently described as "trained immunity," have been documented in plants, invertebrate animals, and mice, but not yet in humans. Here we show that bacille Calmette-Guérin (BCG) vaccination in healthy volunteers led not only to a four- to sevenfold increase in th...

Subject

NOD2

Innate immune system

Immunology

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