The Impact of Tumor Nitric Oxide Production on VEGFA Expression and Tumor Growth in a Zebrafish Rat Glioma Xenograft Model

Yousfi, Nadhir; Pruvot, Benoist; López, Tatiana; Magadoux, Léa; Franche, Nathalie; Pichon, Laurent; Salvadori, Françoise; Solary, Éric; Garrido, Carmen; Laurens, Véronique; Chluba, Johanna

doi:10.1371/journal.pone.0120435

Public

The Impact of Tumor Nitric Oxide Production on VEGFA Expression and Tumor Growth in a Zebrafish Rat Glioma Xenograft Model

Published in PLoS ONE • Mar 13, 2015

Authors:

Nadhir Yousfi

Benoist Pruvot

Tatiana López

Abstract

To investigate the effect of nitric oxide on tumor development, we established a rat tumor xenograft model in zebrafish embryos. The injected tumor cells formed masses in which nitric oxide production could be detected by the use of the cell-permeant DAF-FM-DA (diaminofluorophore 4-amino-5-methylami...

Subject

Nitric oxide

Glioma

Zebrafish

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