Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B.

P, Marcellin; EJ, Heathcote; M, Buti; E, Gane; Man RA, de; Z, Krastev; G, Germanidis; SS, Lee; R, Flisiak; K, Kaita; M, Manns; I, Kotzev; K, Tchernev; P, Buggisch; F, Weilert; OO, Kurdas; ML, Shiffman; H, Trinh; MK, Washington; J, Sorbel; J, Anderson; A, Snow-Lampart; E, Mondou; J, Quinn; F, Rousseau

doi:10.1056/nejmoa0802878

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Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B.

Shared by NobleBlocks on Dec 1, 2008 • 12:00 AM UTC

Authors:

Marcellin P

Heathcote EJ

Buti M

Abstract

Background Tenofovir disoproxil fumarate (DF) is a nucleotide analogue and a potent inhibitor of human immunodeficiency virus type 1 reverse transcriptase and hepatitis B virus (HBV) polymerase.Methods In two double-blind, phase 3 studies, we randomly assigned patients with hepatitis B e antigen (HB...

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