A Peptide c-Jun N-Terminal Kinase (JNK) Inhibitor Blocks Mechanical Allodynia after Spinal Nerve Ligation: Respective Roles of JNK Activation in Primary Sensory Neurons and Spinal Astrocytes for Neuropathic Pain Development and Maintenance

Zhuang, Zhi‐Ye; Wen, Yeong‐Ray; Zhang, De-Ren; Borsello, Tiziana; Bonny, Christophe; R. Strichartz, Gary; Décosterd, Isabelle; Ji, Ru‐Rong

doi:10.1523/jneurosci.5290-05.2006

Public

A Peptide c-Jun N-Terminal Kinase (JNK) Inhibitor Blocks Mechanical Allodynia after Spinal Nerve Ligation: Respective Roles of JNK Activation in Primary Sensory Neurons and Spinal Astrocytes for Neuropathic Pain Development and Maintenance

Published in Journal of Neuroscience • Mar 29, 2006

Authors:

Zhi‐Ye Zhuang

Yeong‐Ray Wen

De-Ren Zhang

Abstract

Optimal management of neuropathic pain is a major clinical challenge. We investigated the involvement of c-Jun N-terminal kinase (JNK) in neuropathic pain produced by spinal nerve ligation (SNL) (L5). SNL induced a slow (>3 d) and persistent (>21 d) activation of JNK, in particular JNK1, in GFAP-exp...

Subject

Neuropathic pain

c-jun

Spinal cord

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