The contrasting mechanisms of serum resistance of Neisseria gonorrhoeae and group B Neisseria meningitidis.

S, Ram; FG, Mackinnon; S, Gulati; DP, McQuillen; U, Vogel; M, Frosch; C, Elkins; HK, Guttormsen; LM, Wetzler; M, Oppermann; MK, Pangburn; PA, Rice

doi:10.1016/s0161-5890(99)00114-5

Public

The contrasting mechanisms of serum resistance of Neisseria gonorrhoeae and group B Neisseria meningitidis.

Shared by NobleBlocks on Sep 1, 1999 • 12:00 AM UTC

Authors:

Ram S

Mackinnon FG

Gulati S

Abstract

Neisseria gonorrhoeae and Neisseria meningitidis have evolved intricate mechanisms to evade complement-mediated killing. Sialylation of gonococcal lipooligosaccharide (LOS) results in conversion of previously serum sensitive strains to unstable serum resistance, which is mediated by factor H binding...

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