The contrasting mechanisms of serum resistance of Neisseria gonorrhoeae and group B Neisseria meningitidis

Ram, Sanjay; G. Mackinnon, Fiona; Gulati, Sunita; P. McQuillen, Daniel; Vogel, Ulrich; Frosch, Matthias; A. Elkins, Christopher; Guttormsen, Hilde‐Kari; M. Wetzler, Lee; Oppermann, Martin; K. Pangburn, Michael; A. Rice, Peter

doi:10.1016/s0161-5890(99)00114-5

Public

The contrasting mechanisms of serum resistance of Neisseria gonorrhoeae and group B Neisseria meningitidis

Published in Molecular Immunology • Sep 1, 1999

Authors:

Sanjay Ram

Fiona G. Mackinnon

Sunita Gulati

Abstract

Neisseria gonorrhoeae and Neisseria meningitidis have evolved intricate mechanisms to evade complement-mediated killing. Sialylation of gonococcal lipooligosaccharide (LOS) results in conversion of previously serum sensitive strains to unstable serum resistance, which is mediated by factor H binding...

Subject

Neisseria gonorrhoeae

Neisseria meningitidis

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