Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis

Zuo, Xianbo; Sun, Liangdan; Yin, Xianyong; Gao, Jinping; Sheng, Yujun; Xu, Jinhua; Zhang, Jianzhong; He, Chundi; Qiu, Ying; Wen, Guangdong; Tian, Hongqing; Zheng, Xiaodong; Liu, Shengxiu; Wang, Wenjun; Li, Weiran; Cheng, Yuyan; Liu, Longdan; Chang, Yan; Wang, Zaixing; Li, Zenggang; Li, Longnian; Wu, Jianping; Fang, Ling; Shen, Changbing; Zhou, Fusheng; Liang, Bo; Chen, Gang; Li, Hui; Cui, Yong; Xu, Aie; Yang, Xueqin; Hao, Fei; Xu, Limin; Fan, Xing; Li, Yuzhen; Wu, Rina; Wang, Xiuli; Liu, Xiaoming; Zheng, Min; Song, Shunpeng; Bi-hua, JI; Fang, Hong; Yu, Jianbin; Sun, Yongxin; Yan, Hui; Zhang, Furen; Yang, Rong; Yang, Sen; Zhang, Xuejun

doi:10.1038/ncomms7793

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Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis

Published in Nature Communications • Apr 9, 2015

Authors:

Xianbo Zuo

Liangdan Sun

Xianyong Yin

Abstract

Genome-wide association studies (GWASs) have reproducibly associated ∼40 susceptibility loci with psoriasis. However, the missing heritability is evident and the contributions of coding variants have not yet been systematically evaluated. Here, we present a large-scale whole-exome array analysis for...

Subject

Missing heritability problem

Genetics

Single-nucleotide polymorphism

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