AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer.

SL, Anzick; J, Kononen; RL, Walker; DO, Azorsa; MM, Tanner; XY, Guan; G, Sauter; OP, Kallioniemi; JM, Trent; PS, Meltzer

doi:10.1126/science.277.5328.965

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AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer.

Shared by NobleBlocks on Aug 1, 1997 • 12:00 AM UTC

Authors:

Anzick SL

Kononen J

Walker RL

Abstract

Members of the recently recognized SRC-1 family of transcriptional coactivators interact with steroid hormone receptors to enhance ligand-dependent transcription. AIB1, a member of the SRC-1 family, was cloned during a search on the long arm of chromosome 20 for genes whose expression and copy numbe...

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