RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

Zhang, Duan-Wu; Shao, Jing; Lin, Juan; Zhang, Na; Lu, Bao-Ju; Lin, Sheng-Cai; Dong, Meng-Qiu; Han, Jiahuai

doi:10.1126/science.1172308

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RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

Shared by NobleBlocks on Jul 17, 2009 • 12:00 AM UTC

Authors:

Duan-Wu Zhang

Jing Shao

Juan Lin

Abstract

The Grim RIPper Cells can undergo regulated cell death through distinct processes known as apoptosis and necrosis. Regulation of apoptosis is better understood than that of necrosis. In a screen for gene products that participate in control of necrosis in cells treated with TNF (tumor necrosis facto...

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