Rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria treated with anti-tumor 1,4-anthracenediones.

Y, Wang; EM, Perchellet; MM, Ward; K, Lou; DH, Hua; JP, Perchellet

doi:10.1097/01.cad.0000180123.24031.5a

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Rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria treated with anti-tumor 1,4-anthracenediones.

Shared by NobleBlocks on Oct 1, 2005 • 12:00 AM UTC

Authors:

Wang Y

Perchellet EM

Ward MM

Abstract

Since synthetic analogs of 1,4-anthraquinone (AQ code number), such as AQ8, AQ9 and AQ10, can trigger cytochrome c release without caspase activation and retain their ability to induce apoptosis in multidrug-resistant (MDR) tumor cells, fluorescent probes of transmembrane potential have been used to...

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