Cross-reactivity of human and murine anti-DNA antibodies with heparan sulfate. The major glycosaminoglycan in glomerular basement membranes.

Faaber, P.; P. M. Rijke, Truus; B van de Putte, L; J Capel, P; H. M. Berden, J.

doi:10.1172/jci112508

Public

Cross-reactivity of human and murine anti-DNA antibodies with heparan sulfate. The major glycosaminoglycan in glomerular basement membranes.

Published in Journal of Clinical Investigation • Jun 1, 1986

Authors:

P. Faaber

Truus P. M. Rijke

L B van de Putte

Abstract

In 30 of 33 human systemic lupus erythematosus (SLE) sera and in 10 sera from MRL/l mice with spontaneous SLE, antibodies against heparan sulfate were detected. The anti-heparan sulfate titers showed a significant correlation with the anti-DNA antibody titers. By inhibition studies it was demonstrat...

Subject

Heparan sulfate

Perlecan

Glomerular basement membrane

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