The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

Zhang, Jinghui; Ding, Li; Holmfeldt, Linda; Wu, Gang; L. Heatley, Susan; Payne-Turner, Debbie; Easton, John; Chen, Xiang; Wang, Jianmin; Rusch, Michael; Lu, Charles; Chen, Shann-Ching; Wei, Lei; Racquel Collins-Underwood, J.; Ma, Jing; G. Roberts, Kathryn; Pounds, Stanley; Ulyanov, Anatoly; Becksfort, Jared; Gupta, Pankaj; Huether, Robert; W. Kriwacki, Richard; Parker, Matthew; McGoldrick, Daniel; Zhao, David; P. Alford, Daniel; Espy, Stephen; Chand Bobba, Kiran; Song, Guangchun; Pei, Deqing; Cheng, Cheng; Roberts, Stefan; I. Barbato, Michael; Campana, Dario; Coustan‐Smith, Elaine; Shurtleff, Sheila; C. Raimondi, Susana; Kleppe, Maria; Cools, Jan; A. Shimano, Kristin; L. Hermiston, Michelle; Doulatov, Sergei; Eppert, Kolja; Laurenti, Elisa; Notta, Faiyaz; E. Dick, John; Basso, Giuseppe; P. Hunger, Stephen; L. Loh, Mignon; Devidas, Meenakshi; L. Wood, Brent; S. Winter, Stuart; P. Dunsmore, Kimberly; S. Fulton, Robert; Fulton, Lucinda; Hong, Xin; Harris, Christopher; J. Dooling, David; Ochoa, Kerri; Johnson, Kimberly; C. Obenauer, John; E. Evans, William; Pui, Ching‐Hon; W. Naeve, Clayton; J. Ley, Timothy; R. Mardis, Elaine; K. Wilson, Richard; R. Downing, James; G. Mullighan, Charles

doi:10.1038/nature10725

Public

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

Published in Nature • Jan 1, 2012

Authors:

Jinghui Zhang

Li Ding

Linda Holmfeldt

Abstract

Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole-genome sequencing of 12 ETP ALL cases and assessed the frequency of the identified somatic mutations in 94 T-cell acute lymphoblastic leukaemia cases. ETP ALL was c...

Subject

Myeloid

Cancer research

Haematopoiesis

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