Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

Ann Pelleymounter, Mary; Jane Cullen, Mary; Baker, Mary; Hecht, Randy; Winters, Dwight; C. Boone, Thomas; M. Collins, Frank

doi:10.1126/science.7624776

Public

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

Published in Science • Jul 28, 1995

Authors:

Mary Ann Pelleymounter

Mary Jane Cullen

Mary Baker

Abstract

C57BL/6J mice with a mutation in the obese (ob) gene are obese, diabetic, and exhibit reduced activity, metabolism, and body temperature. Daily intraperitoneal injection of these mice with recombinant OB protein lowered their body weight, percent body fat, food intake, and serum concentrations of gl...

Subject

Internal medicine

Endocrinology

Body weight

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