Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development.

Hadchouel, Alice; Decobert, Fabrice; Franco-Montoya, Marie-Laure; Halphen, Isabelle; Jarreau, Pierre-Henri; Boucherat, Olivier; Martin, Emmanuel; Benachi, Alexandra; Amselem, Serge; Bourbon, Jacques; Danan, Claude; Delacourt, Christophe

doi:10.1371/journal.pone.0003188

Public

Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development.

Shared by NobleBlocks on Sep 11, 2008 • 12:00 AM UTC

Authors:

Alice Hadchouel

Fabrice Decobert

Marie-Laure Franco-Montoya

Abstract

BACKGROUND: Alveolarization requires coordinated extracellular matrix remodeling, a process in which matrix metalloproteinases (MMPs) play an important role. We postulated that polymorphisms in MMP genes might affect MMP function in preterm lungs and thus influence the risk of bronchopulmonary dyspl...

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