Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA

E. Squires, Jeffrey; R. Patel, Hardip; Nousch, Marco; Sibbritt, Tennille; T. Humphreys, David; J. Parker, Brian; M. Suter, Catherine; Preiß, Thomas

doi:10.1093/nar/gks144

Public

Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA

Published in Nucleic Acids Research • Feb 16, 2012

Authors:

Jeffrey E. Squires

Hardip R. Patel

Marco Nousch

Abstract

The modified base 5-methylcytosine (m(5)C) is well studied in DNA, but investigations of its prevalence in cellular RNA have been largely confined to tRNA and rRNA. In animals, the two m(5)C methyltransferases NSUN2 and TRDMT1 are known to modify specific tRNAs and have roles in the control of cell ...

Subject

Biology

RNA

Transfer RNA

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