Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

J. Sime, Patricia; Xing, Z; L. Graham, Frank; G. Csaky, Karl; Gauldie, Jack

doi:10.1172/jci119590

Public

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

Published in Journal of Clinical Investigation • Aug 15, 1997

Authors:

Patricia J. Sime

Z Xing

Frank L. Graham

Abstract

Transforming growth factor (TGF)-beta1 has been implicated in the pathogenesis of fibrosis based upon its matrix-inducing effects on stromal cells in vitro, and studies demonstrating increased expression of total TGF-beta1 in fibrotic tissues from a variety of organs. The precise role in vivo of thi...

Subject

Extracellular matrix

Pulmonary fibrosis

Transforming growth factor

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