CTLA-4 Control over Foxp3 <sup>+</sup> Regulatory T Cell Function

Wing, Kajsa; Onishi, Yasushi; Prieto-Martin, Paz; Yamaguchi, Tomoyuki; Miyara, Makoto; Fehérvári, Zoltán; Nomura, Takashi; Sakaguchi, Shimon

doi:10.1126/science.1160062

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CTLA-4 Control over Foxp3 + Regulatory T Cell Function

Published in Science • Oct 10, 2008

Authors:

Kajsa Wing

Yasushi Onishi

Paz Prieto-Martin

Abstract

Naturally occurring Foxp3+CD4+ regulatory T cells (Tregs) are essential for maintaining immunological self-tolerance and immune homeostasis. Here, we show that a specific deficiency of cytotoxic T lymphocyte antigen 4 (CTLA-4) in Tregs results in spontaneous development of systemic lymphoproliferati...

Subject

Function (biology)

Cell function

Chemistry

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