Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation.

Westermark, Per; Engström, Ulla; H. Johnson, Kenneth; T. Westermark, Gunilla; Betsholtz, Christer

doi:10.1073/pnas.87.13.5036

Public

Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation.

Published in Proceedings of the National Academy of Sciences • Jul 1, 1990

Authors:

Per Westermark

Ulla Engström

Kenneth H. Johnson

Abstract

Islet amyloid polypeptide (IAPP), a putative polypeptide hormone, is a product of pancreatic beta-cells and the major constituent of the amyloid deposits seen mainly in islets of type 2 diabetic humans and diabetic cats. The connection between IAPP amyloid formation and diabetes is unknown, but a li...

Subject

Islet

Amyloid (mycology)

Fibril

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