Mal Interacts with Tumor Necrosis Factor Receptor-associated Factor (TRAF)-6 to mediate NF-κB Activation by Toll-like Receptor (TLR)-2 and TLR4

Mansell, Ashley; Brint, Elizabeth; A. Gould, Jodee; O'neill, Luke; J. Hertzog, Paul

doi:10.1074/jbc.c400289200

Public

Mal Interacts with Tumor Necrosis Factor Receptor-associated Factor (TRAF)-6 to mediate NF-κB Activation by Toll-like Receptor (TLR)-2 and TLR4

Published in Journal of Biological Chemistry • Jul 10, 2004

Authors:

Ashley Mansell

Elizabeth Brint

Jodee A. Gould

Abstract

The Toll-interleukin-1 receptor domain-containing adapter Mal (MyD88 adapter-like protein) is involved in Toll-like receptor (TLR)-2 and TLR4 signal transduction. However, no studies have yet identified a function for Mal distinct from the related adapter MyD88. In this study, we have identified a p...

Subject

Toll-like receptor

TLR4

Receptor

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