Negative Regulation of Neural Stem/Progenitor Cell Proliferation by the <i>Pten</i> Tumor Suppressor Gene in Vivo

Groszer, Matthias; J. Erickson, Rebecca; D. Scripture-Adams, Deirdre; Lesche, Ralf; Trumpp, Andreas; A. Zack, Jerome; I. Kornblum, Harley; Liu, Xin; Wu, Hong

doi:10.1126/science.1065518

Public

Negative Regulation of Neural Stem/Progenitor Cell Proliferation by the Pten Tumor Suppressor Gene in Vivo

Published in Science • Dec 7, 2001

Authors:

Matthias Groszer

Rebecca J. Erickson

Deirdre D. Scripture-Adams

Abstract

The mechanisms controlling neural stem cell proliferation are poorly understood. Here we demonstrate that the PTEN tumor suppressor plays an important role in regulating neural stem/progenitor cells in vivo and in vitro. Mice lacking PTEN exhibited enlarged, histoarchitecturally abnormal brains, whi...

Subject

PTEN

Progenitor cell

Neurosphere

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