MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia

Garzon, Ramiro; Volinia, Stefano; Liu, Chang–Gong; Fernandez-Cymering, Cecilia; Palumbo, Tiziana; Pichiorri, Flavia; Fabbri, Muller; R. Coombes, Kevin; Alder, Hansjüerg; Nakamura, Tatsuya; Flomenberg, Neal; Marcucci, Guido; A. Calin, George; M. Kornblau, Steven; M. Kantarjian, Hagop; D. Bloomfield, Clara; Andreeff, Michael; M. Croce, Carlo

doi:10.1182/blood-2007-07-098749

Public

MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia

Published in Blood • Jan 10, 2008

Authors:

Ramiro Garzon

Stefano Volinia

Chang–Gong Liu

Abstract

MicroRNAs (miRNAs) are small RNAs of 19 to 25 nucleotides that are negative regulators of gene expression. To determine whether miRNAs are associated with cytogenetic abnormalities and clinical features in acute myeloid leukemia (AML), we evaluated the miRNA expression of CD34(+) cells and 122 untre...

Subject

Cytogenetics

Myeloid leukemia

microRNA

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