Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c

Liang, Guosheng; Yang, Jian; D. Horton, Jay; E. Hammer, Robert; L. Goldstein, Joseph; S. Brown, Michael

doi:10.1074/jbc.m111421200

Public

Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c

Published in Journal of Biological Chemistry • Mar 1, 2002

Authors:

Guosheng Liang

Jian Yang

Jay D. Horton

Abstract

Two treatments, fasting/refeeding and administration of liver X receptor (LXR) agonists, elevate the mRNA for sterol regulatory element-binding protein-1c (SREBP-1c) and enhance lipid synthesis in liver. These treatments do not affect the mRNA for SREBP-1a, an alternative transcript from the same ge...

Subject

Sterol regulatory element-binding protein

Fatty acid synthase

Fatty acid synthesis

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