Naturally Acquired Antibodies to Sporozoites Do Not Prevent Malaria: Vaccine Development Implications

L. Hoffman, Stephen; N. Oster, Charles; V. Plowe, Christopher; R. Woollett, Gillian; C. Beier, John; D. Chulay, Jeffrey; A. Wirtz, Robert; R. Hollingdale, Michael; Mugambi, Mutuma

doi:10.1126/science.3299709

Public

Naturally Acquired Antibodies to Sporozoites Do Not Prevent Malaria: Vaccine Development Implications

Published in Science • Aug 7, 1987

Authors:

Stephen L. Hoffman

Charles N. Oster

Christopher V. Plowe

Abstract

The first human vaccines against the malaria parasite have been designed to elicit antibodies to the circumsporozoite protein of Plasmodium falciparum. However, it is not known whether any level of naturally acquired antibodies to the circumsporozoite protein can predict resistance to Plasmodium fal...

Subject

Circumsporozoite protein

Malaria

Parasitemia

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