A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells

Chabannes, Dominique; Hill, Marcelo; Mérieau, Emmanuel; Rossignol, Julien; Brion, Régis; Paul Soulillou, Jean; Anegón, Ignacio; Cristina Cuturi, María

doi:10.1182/blood-2007-02-075481

Public

A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells

Published in Blood • Aug 7, 2007

Authors:

Dominique Chabannes

Marcelo Hill

Emmanuel Mérieau

Abstract

Mesenchymal stem cells (MSCs) display immunomodulatory properties mediated by various factors, including inducible nitric oxide synthase (iNOS). Since heme oxygenase-1 (HO-1) is a potent immunosuppressive enzyme, we tested the hypothesis that HO-1 could mediate the immunosuppressive effects of MSCs....

Subject

Mesenchymal stem cell

Heme oxygenase

In vitro

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