The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

Stransky, Nicolas; Marie Egloff, Ann; D. Tward, Aaron; D. Kostic, Aleksandar; Cibulskis, Kristian; Sivachenko, Andrey; V. Kryukov, Gregory; S. Lawrence, Michael; Sougnez, Carrie; McKenna, Aaron; Shefler, Erica; H. Ramos, Alex; Stojanov, Petar; L. Carter, Scott; Voet, Douglas; L. Cortés, Maria; Auclair, Daniel; F. Berger, Michael; Saksena, Gordon; Guiducci, Candace; C. Onofrio, Robert; Parkin, Melissa; Romkes, Marjorie; L. Weissfeld, Joel; R. Seethala, Raja; Wang, Lin; Rangel‐Escareño, Claudia; Carlos Fernández-López, Juan; Hidalgo‐Miranda, Alfredo; Meléndez-Zajgla, Jorge; Winckler, Wendy; Ardlie, Kristin; Gabriel, Stacey; Meyerson, Matthew; S. Lander, Eric; Getz, Gad; R. Golub, Todd; A. Garraway, Levi; R. Grandis, Jennifer

doi:10.1126/science.1208130

Public

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

Published in Science • Jul 28, 2011

Authors:

Nicolas Stransky

Ann Marie Egloff

Aaron D. Tward

Abstract

Head and neck squamous cell carcinoma (HNSCC) is a common, morbid, and frequently lethal malignancy. To uncover its mutational spectrum, we analyzed whole-exome sequencing data from 74 tumor-normal pairs. The majority exhibited a mutational profile consistent with tobacco exposure; human papillomavi...

Subject

Head and neck

Basal cell

Head and neck squamous-cell carcinoma

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