Quantum Dot−Aptamer Conjugates for Synchronous Cancer Imaging, Therapy, and Sensing of Drug Delivery Based on Bi-Fluorescence Resonance Energy Transfer

Bagalkot, Vaishali; Zhang, Liangfang; Levy‐Nissenbaum, Etgar; Jon, Sangyong; W. Kantoff, Philip; Langer, Róbert; C. Farokhzad, Omid

doi:10.1021/nl071546n

Public

Quantum Dot−Aptamer Conjugates for Synchronous Cancer Imaging, Therapy, and Sensing of Drug Delivery Based on Bi-Fluorescence Resonance Energy Transfer

Published in Nano Letters • Sep 14, 2007

Authors:

Vaishali Bagalkot

Liangfang Zhang

Etgar Levy‐Nissenbaum

Abstract

We report a novel quantum dot (QD)-aptamer(Apt)-doxorubicin (Dox) conjugate [QD-Apt(Dox)] as a targeted cancer imaging, therapy, and sensing system. By functionalizing the surface of fluorescent QD with the A10 RNA aptamer, which recognizes the extracellular domain of the prostate specific membrane ...

Subject

Aptamer

Förster resonance energy transfer

Drug delivery

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