Intravenous Administration of 99m Tc-HMPAO-Labeled Human Mesenchymal Stem Cells after Stroke: In Vivo Imaging and Biodistribution

Detante, Olivier; Moisan, Anaïck; Dimastromatteo, Julien; Richard, Marie‐Jeanne; Riou, Laurent; Grillon, Emmanuelle; Barbier, Emmanuel; Desruet, Marie-Dominique; de Fraipont, Florence; Segebarth, Christoph; Jaillard, Assia; Hommel, Marc; Ghezzi, Cathérine; Rémy, Chantal

doi:10.3727/096368909x474230

Public

Intravenous Administration of 99m Tc-HMPAO-Labeled Human Mesenchymal Stem Cells after Stroke: In Vivo Imaging and Biodistribution

Published in Cell Transplantation • Dec 1, 2009

Authors:

Olivier Detante

Anaïck Moisan

Julien Dimastromatteo

Abstract

Human mesenchymal stem cells (hMSC) are a promising source for cell therapy after stroke. To deliver these cells, an IV injection appears safer than a local graft. We aimed to assess the whole-body biodistribution of IV-injected (99m)Tc-HMPAO-labeled hMSC in normal rats (n = 9) and following a right...

Subject

Biodistribution

Spleen

Mesenchymal stem cell

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