Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia

Nair, Parameswaran; Margaret Menezes Pizzichini, Márcia; Kjarsgaard, Melanie; D. Inman, Mark; Efthimiadis, Ann; Pizzichini, Emílio; E. Hargreave, Frederick; M. O’Byrne, Paul

doi:10.1056/nejmoa0805435

Public

Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia

Published in New England Journal of Medicine • Mar 4, 2009

Authors:

Parameswaran Nair

Márcia Margaret Menezes Pizzichini

Melanie Kjarsgaard

Abstract

BACKGROUND: Eosinophilic inflammation, which may be a consequence of interleukin-5 action, is a characteristic feature of some forms of asthma. However, in three previous clinical trials involving patients with asthma, blockade of this cytokine did not result in a significant improvement in outcomes...

Subject

Mepolizumab

Medicine

Prednisone

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