ERK1/2 mediates TNF‐α‐induced matrix metalloproteinase‐9 expression in human vascular smooth muscle cells via the regulation of NF‐κB and AP‐1: Involvement of the ras dependent pathway

Moon, Sung‐Kwon; Cha, Byung‐Yoon; Kim, Cheorl‐Ho

doi:10.1002/jcp.10435

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ERK1/2 mediates TNF‐α‐induced matrix metalloproteinase‐9 expression in human vascular smooth muscle cells via the regulation of NF‐κB and AP‐1: Involvement of the ras dependent pathway

Published in Journal of Cellular Physiology • Oct 7, 2003

Authors:

Sung‐Kwon Moon

Byung‐Yoon Cha

Cheorl‐Ho Kim

Abstract

The expression of matrix metalloproteinase-9 (MMP-9) has been implicated in progression of atherosclerotic lesions. The role and importance of the signaling pathway in the transcriptional regulation of MMP-9 in human aortic smooth muscle cells (HASMC) was examined. Tumor necrosis factor-alpha (TNF-a...

Subject

MAPK/ERK pathway

Transactivation

Tumor necrosis factor alpha

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