Unexpected Inhibition of Peptidoglycan LD-Transpeptidase from Enterococcus faecium by the β-Lactam Imipenem

Mainardi, Jean‐Luc; Hugonnet, Jean‐Emmanuel; Rusconi, Filippo; Fourgeaud, Martine; Dubost, Lionel; Nguekam Moumi, Angèle; Delfosse, V.; Mayer, Claudine; Gutmann, Laurent; B. Rice, Louis; Arthur, Michel

doi:10.1074/jbc.m704286200

Public

Unexpected Inhibition of Peptidoglycan LD-Transpeptidase from Enterococcus faecium by the β-Lactam Imipenem

Published in Journal of Biological Chemistry • Jul 24, 2007

Authors:

Jean‐Luc Mainardi

Jean‐Emmanuel Hugonnet

Filippo Rusconi

Abstract

The beta-lactam antibiotics mimic the D-alanyl(4)-D-alanine(5) extremity of peptidoglycan precursors and act as "suicide" substrates of the DD-transpeptidases that catalyze the last cross-linking step of peptidoglycan synthesis. We have previously shown that bypass of the dd-transpeptidases by the L...

Subject

Peptidoglycan

Imipenem

Chemistry

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!