3-Mercaptopyruvate Sulfurtransferase Produces Hydrogen Sulfide and Bound Sulfane Sulfur in the Brain

Shibuya, Norihiro; Tanaka, M.; Yoshida, Mikiharu; Ogasawara, Yuki; Togawa, Tadayasu; Ishii, Kazuyuki; Kimura, Hideo

doi:10.1089/ars.2008.2253

Public

3-Mercaptopyruvate Sulfurtransferase Produces Hydrogen Sulfide and Bound Sulfane Sulfur in the Brain

Published in Antioxidants and Redox Signaling • Oct 14, 2008

Authors:

Norihiro Shibuya

M. Tanaka

Mikiharu Yoshida

Abstract

Hydrogen sulfide (H(2)S) is a synaptic modulator as well as a neuroprotectant. Currently, pyridoxal-5'-phosphate (PLP)-dependent cystathionine beta-synthase (CBS) is thought to be the major H(2)S-producing enzyme in the brain. We recently found that brain homogenates of CBS-knockout mice, even in th...

Subject

Sulfurtransferase

Cystathionine beta synthase

Cysteine

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