Age and Relative Adiposity Are Specific Negative Determinants of the Frequency and Amplitude of Growth Hormone (GH) Secretory Bursts and the Half-Life of Endogenous GH in Healthy Men*

Iranmanesh, Ali; LIZARRALDE, GERMAN; D. Veldhuis, Johannes

doi:10.1210/jcem-73-5-1081

Public

Age and Relative Adiposity Are Specific Negative Determinants of the Frequency and Amplitude of Growth Hormone (GH) Secretory Bursts and the Half-Life of Endogenous GH in Healthy Men*

Published in The Journal of Clinical Endocrinology & Metabolism • Nov 1, 1991

Authors:

Ali Iranmanesh

GERMAN LIZARRALDE

Johannes D. Veldhuis

Abstract

Mean plasma GH concentrations are controlled by the frequency, amplitude, and duration of underlying GH secretory bursts as well as by the half-life of endogenous GH. We investigated the specific mechanisms that subserve the clinically recognized negative effects of age and adiposity on mean serum G...

Subject

Endocrinology

Internal medicine

Endogeny

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