p53-related apoptosis resistance and tumor suppression activity in UVB-induced premature senescent human skin fibroblasts

Chen, Wenqi; Kang, Jian; Xia, Jiping; Li, Yanhua; Yang, Bo; Chen, Bin; Sun, Weiling; Song, Xiuzu; WenZhong, Xiang; Wang, Xiaoyong; Wang, Fei; Wan, Yinsheng; Zhi-gang, BI

doi:10.3892/ijmm.21.5.645

Public

p53-related apoptosis resistance and tumor suppression activity in UVB-induced premature senescent human skin fibroblasts

Published in International Journal of Molecular Medicine • May 1, 2008

Authors:

Wenqi Chen

Jian Kang

Jiping Xia

Abstract

Chronic exposure to solar UV irradiation leads to photoaging, immunosuppression, and ultimately carcinogenesis. Cellular senescence is thought to play an important role in tumor suppression and apoptosis resistance. However, the relationships among stress-induced premature senescence (SIPS), tumorig...

Subject

Senescence

Carcinogenesis

Apoptosis

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