CD1d, a Sentinel Molecule Bridging Innate and Adaptive Immunity, Is Downregulated by the Human Papillomavirus (HPV) E5 Protein: a Possible Mechanism for Immune Evasion by HPV

Miura, Shiho; Kawana, Kei; J. Schust, Danny; Fujii, Tomoyuki; Yokoyama, Terufumi; Iwasawa, Yuki; Nagamatsu, Takeshi; Adachi, Katsuyuki; Tomio, Ayako; Tomio, Kensuke; Kojima, Satoko; Yasugi, Toshiharu; Kozuma, Shiro; Taketani, Yuji

doi:10.1128/jvi.01053-10

Public

CD1d, a Sentinel Molecule Bridging Innate and Adaptive Immunity, Is Downregulated by the Human Papillomavirus (HPV) E5 Protein: a Possible Mechanism for Immune Evasion by HPV

Shared by NobleBlocks on Nov 15, 2010 • 12:00 AM UTC

Authors:

Shiho Miura

Kei Kawana

Danny J. Schust

Abstract

ABSTRACT CD1d and CD1d-restricted natural killer T (NKT) cells serve as a natural bridge between innate and adaptive immune responses to microbes. CD1d downregulation is utilized by a variety of microbes to evade immune detection. We demonstrate here that CD1d is downregulated in human papillomaviru...

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