Cyanobacterial microcystin‐LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants

MacKintosh, Carol; A. Beattie, Kenneth; Klumpp, Susanne; Cohen, Philip; A. Codd, Geoffrey

doi:10.1016/0014-5793(90)80245-e

Public

Cyanobacterial microcystin‐LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants

Published in FEBS Letters • May 21, 1990

Authors:

Carol MacKintosh

Kenneth A. Beattie

Susanne Klumpp

Abstract

The cyclic heptapeptide, microcystin-LR, inhibits protein phosphatases 1 (PP1) and 2A (PP2A) with Ki values below 0.1 nM. Protein phosphatase 2B is inhibited 1000-fold less potently, while six other phosphatases and eight protein kinases tested are unaffected. These results are strikingly similar to...

Subject

Okadaic acid

Phosphatase

Microcystin-LR

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