BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development

Shu, Bing; Zhang, Ming; Xie, Rong; Wang, Meina; Jin, Hongting; Hou, Wei; Tang, Dezhi; E. Harris, Stephen; Mishina, Yuji; J. O’Keefe, Regis; J. Hilton, Matthew; Wang, Yongjun; Chen, Di

doi:10.1242/jcs.083659

Public

BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development

Published in Journal of Cell Science • Oct 8, 2011

Authors:

Bing Shu

Ming Zhang

Rong Xie

Abstract

The BMP signaling pathway has a crucial role in chondrocyte proliferation and maturation during endochondral bone development. To investigate the specific function of the Bmp2 and Bmp4 genes in growth plate chondrocytes during cartilage development, we generated chondrocyte-specific Bmp2 and Bmp4 co...

Subject

Chondrocyte

RUNX2

Bone morphogenetic protein 2

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