Corticotropin-Releasing Hormone and Oxytocin Stimulate the Release of Placental Proopiomelanocortin Peptides

N. Margioris, Andrew; Grino, Michel; PROTOS, PETER; W. Gold, Philip; P. Chrousos, George

doi:10.1210/jcem-66-5-922

Public

Corticotropin-Releasing Hormone and Oxytocin Stimulate the Release of Placental Proopiomelanocortin Peptides

Published in The Journal of Clinical Endocrinology & Metabolism • May 1, 1988

Authors:

Andrew N. Margioris

Michel Grino

PETER PROTOS

Abstract

Human placenta contains the POMC-derived peptides ACTH, alpha MSH, and beta-endorphin, and CRH. High concentrations of immunoreactive (IR) CRH have been recently demonstrated in maternal plasma during pregnancy. To determine if the human placenta secretes CRH and POMC-derived peptides, we developed ...

Subject

Internal medicine

Endocrinology

Oxytocin

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