Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation

Maria Spaggiari, Grazia; Capobianco, Andrea; Becchetti, S.; Cristina Mingari, Maria; Moretta, Lorenzo

doi:10.1182/blood-2005-07-2775

Public

Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation

Published in Blood • Oct 26, 2005

Authors:

Grazia Maria Spaggiari

Andrea Capobianco

S. Becchetti

Abstract

In recent years, mesenchymal stem cells (MSCs) have been shown to inhibit T-lymphocyte proliferation induced by alloantigens or mitogens. However, no substantial information is available regarding their effect on natural killer (NK) cells. Here we show that MSCs sharply inhibit IL-2-induced prolifer...

Subject

NKG2D

Mesenchymal stem cell

Interleukin 12

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