Novel Bioactive Clerodane Diterpenoids from the Leaves and Twigs of Casearia sylvestris

H. Oberlies, Nicholas; P. Burgess, Jason; A. Navarro, Hernán; Elena Pinos, Rosa; R. Fairchild, Craig; W. Peterson, Russell; D. Soejarto, Djaja; R. Farnsworth, Norman; Douglas Kinghorn, A.; C. Wani, Mansukh; E. Wall, Monroe

doi:10.1021/np010459m

Public

Novel Bioactive Clerodane Diterpenoids from the Leaves and Twigs of Casearia sylvestris

Published in Journal of Natural Products • Jan 8, 2002

Authors:

Nicholas H. Oberlies

Jason P. Burgess

Hernán A. Navarro

Abstract

Fractionation of a methanol extract of the leaves and twigs of Casearia sylvestris, as directed by activity against KB cell cytotoxicity, led to the isolation of three novel clerodane diterpenoids, casearvestrins A-C (1-3). The structures of 1-3 were deduced from one- and two-dimensional NMR experim...

Subject

Cytotoxicity

Stereochemistry

Two-dimensional nuclear magnetic resonance spectroscopy

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