N -Methylated Cyclic RGD Peptides as Highly Active and Selective α V β 3 Integrin Antagonists

A. Dechantsreiter, Michael; Planker, Eckart; Mathä, Barbara; Lohof, Elisabeth; Hölzemann, Günter; Jonczyk, Alfred; L. Goodman, Simon; Kessler, Horst

doi:10.1021/jm970832g

Public

N -Methylated Cyclic RGD Peptides as Highly Active and Selective α V β 3 Integrin Antagonists

Published in Journal of Medicinal Chemistry • Jul 24, 1999

Authors:

Michael A. Dechantsreiter

Eckart Planker

Barbara Mathä

Abstract

The alpha(V)beta(3) integrin receptor plays an important role in human tumor metastasis and tumor-induced angiogenesis. The in vivo inhibition of this receptor by antibodies or by cyclic peptides containing the RGD sequence may in the future be used to selectively suppress these diseases. Here we in...

Subject

Vitronectin

Chemistry

Integrin

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