Gender-related effects on metoprolol pharmacokinetics and pharmacodynamics in healthy volunteers

B Luzier, Aileen; KILLIAN, A; WILTON, J; WILSON, M; Forrest, Alan; KAZIERAD, D

doi:10.1053/cp.1999.v66.103400001

Public

Gender-related effects on metoprolol pharmacokinetics and pharmacodynamics in healthy volunteers

Published in Clinical Pharmacology & Therapeutics • Dec 1, 1999

Authors:

Aileen B Luzier

A KILLIAN

J WILTON

Abstract

OBJECTIVE: To determine whether there are gender-specific differences in the pharmacokinetics and pharmacodynamics of metoprolol enantiomers. METHODS: Twenty normal volunteers (10 men and 10 women) received 100 mg oral metoprolol tartrate twice daily for a total of nine doses. Pharmacokinetics and p...

Subject

Metoprolol

Pharmacodynamics

Pharmacokinetics

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