Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor

B. Schreiber, Alain; E. Winkler, Marjorie; Derynck, Rik

doi:10.1126/science.2422759

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Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor

Published in Science • Jun 6, 1986

Authors:

Alain B. Schreiber

Marjorie E. Winkler

Rik Derynck

Abstract

Transforming growth factor-alpha (TGF-alpha) and epidermal growth factor (EGF) are structurally related peptides. Purified human TGF-alpha produced in Escherichia coli and pure natural mouse EGF were compared for their ability to bind to target cells in vitro and to promote angiogenesis in the hamst...

Subject

Epidermal growth factor

Angiogenesis

Transforming growth factor

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