PROLONGED ACTION OF A CHIMERIC INTERLEUKIN-2 RECEPTOR (CD25) MONOCLONAL ANTIBODY USED IN CADAVERIC RENAL TRANSPLANTATION

L Amlot, P; Rawlings, E; N. Fernando, Ossie; Griffin, Peter; Heinrich, Günther; H. Schreier, Max; Castaigne, Jean‐Paul; H. Moore, Richard; Sweny, P.

doi:10.1097/00007890-199510150-00023

Public

PROLONGED ACTION OF A CHIMERIC INTERLEUKIN-2 RECEPTOR (CD25) MONOCLONAL ANTIBODY USED IN CADAVERIC RENAL TRANSPLANTATION

Published in Transplantation • Oct 1, 1995

Authors:

P L Amlot

E Rawlings

Ossie N. Fernando

Abstract

A high affinity chimeric CD25 mAb (chRFT5: SDZ CHI 621) blocking interleukin-2 binding to the interleukin-2 receptor alpha-chain was evaluated in a phase I/II study in human renal cadaveric transplantation. The chRFT5 was well tolerated with no immediate adverse effects during 6 spaced infusions (fr...

Subject

Medicine

Transplantation

Monoclonal antibody

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