Using Multiplexed Assays of Oncogenic Drivers in Lung Cancers to Select Targeted Drugs

G. Kris, Mark; E. Johnson, Bruce; D. Berry, Lynne; J. Kwiatkowski, David; John Iafrate, A.; I. Wistuba, Ignacio; Varella‐Garcia, Marileila; A. Franklin, Wilbur; L. Aronson, Samuel; Su, Pei-Fang; Shyr, Yu; Ross Camidge, D.; V. Sequist, Lecia; S. Glisson, Bonnie; R. Khuri, Fadlo; B. Garon, Edward; Pao, William; M. Rudin, Charles; H. Schiller, Joan; B. Haura, Eric; A. Socinski, Mark; Shirai, Keisuke; Chen, Heidi; Giaccone, Giuseppe; Ladanyi, Marc; Kugler, Kelly; D. Minna, John; A. Bunn, Paul

doi:10.1001/jama.2014.3741

Public

Using Multiplexed Assays of Oncogenic Drivers in Lung Cancers to Select Targeted Drugs

Published in JAMA • May 20, 2014

Authors:

Mark G. Kris

Bruce E. Johnson

Lynne D. Berry

Abstract

IMPORTANCE: Targeting oncogenic drivers (genomic alterations critical to cancer development and maintenance) has transformed the care of patients with lung adenocarcinomas. The Lung Cancer Mutation Consortium was formed to perform multiplexed assays testing adenocarcinomas of the lung for drivers in...

Subject

KRAS

Medicine

Lung cancer

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